In a bowl, add the chicken tenders and pour in the buttermilk. Toss to coat and let it marinate in the refrigerator for at least 30 minutes to 2 hours.
Preheat your oven to 400°F (200°C) and line a baking sheet with parchment paper. In one shallow dish, mix the flour, garlic powder, onion powder, paprika, salt, black pepper, and cayenne pepper. In a second shallow dish, place the breadcrumbs.
Remove the chicken tenders from the buttermilk, allowing the excess to drip off. Dip each tender in the flour mixture, coating it evenly, then dip it into the breadcrumb mixture, pressing gently for an even coating.
Place the coated chicken tenders on the prepared baking sheet. Lightly spray or drizzle with cooking spray or olive oil.
Bake in the preheated oven for 15-20 minutes or until the chicken is golden brown and cooked through, reaching an internal temperature of 165°F (74°C). Flip the tenders halfway through.
Once done, remove the tenders from the oven and allow them to rest for a few minutes. Serve with your favorite dipping sauces.